Of the rats with heart failure that were fed TMAO, all of them survived the year, while one third of rats with heart failure that were not fed TMAO died. fed the compound to healthy rats and rats with heart failure for one year. To assess the effects of dietary TMAO on heart failure, Gawrys-Kopczynska et al. A toxic byproduct of gut bacteria called TMA is converted in TMAO in the body, so it is possible that TMA rather than TMAO is to blame. Increased levels of TMAO in the blood are associated with cardiovascular diseases, but scientists are not sure whether TMAO itself harms the heart.
In humans, eating seafood increases TMAO levels in the blood and urine, but it is unclear what effects this has on heart health.
Fish that live in deep waters undergo high pressures, which can damage their proteins, but TMAO seems to protect the proteins from harm. Seafood also contains other compounds, including trimethylamine oxide (TMAO). The Japanese diet is rich in seafood, which contains nutrients that promote heart health, such as omega-3 fatty acids. Dietary differences between these regions may explain the lower rate of heart failure in Japan. Japan, however, has lower rates of heart failure and fewer deaths linked to this disease than the United States or Europe, despite having the highest proportion of elderly people in the world. Heart failure is a common cause of death in industrialized countries with aging populations. HPS and TMAO did not affect LDH protein structure. In conclusion, TMAO reduced mortality in SHHF, which was associated with diuretic, natriuretic and hypotensive effects. In vitro, exposure of LDH to HPS with or without TMAO did not affect protein structure. Survival in SHHF-control was 66% vs 100% in SHHF-TMAO. TMAO-treated rats showed higher diuresis and natriuresis, lower arterial pressure and plasma NT-proBNP. In vitro, LDH with or without TMAO was exposed to HPS and was evaluated using fluorescence correlation spectroscopy.
Male, Sprague-Dawley and Spontaneously-Hypertensive-Heart-Failure (SHHF) rats were treated orally with either water (control) or TMAO. We hypothesized that TMAO exerts beneficial effects on the circulatory system and protects cardiac LDH exposed to HPS produced by the contracting heart. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS). Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health.
0 kommentar(er)
